Summer 2014

American Association for Cancer Research

Studies Reveal More Clues on How Full-Term Pregnancy Protects Against Breast Cancer At the AACR 2014 Annual Meeting in San Diego, Fox Chase scientists presented findings from three studies that examined how pregnancy reduces women’s risk of developing breast cancer. In the first study, Julia Santucci-Pereira, PhD, a research associate in the Breast Cancer Research Laboratory led by Jose Russo, MD, FACP, and colleagues used gene expression microarrays to compare the breast genomic profiles of cancer-free breast tissue samples from more than 100 premenopausal women — 79 parous, 30 nulliparous. They found that immune response genes are activated for a … Continue Reading »

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Pain and Palliative Care Program Receives Joint Commission Advanced Certification

In April, Fox Chase’s pain and palliative care program received its advanced certification from The Joint Commission. Fox Chase is one of only five facilities in the region that has achieved this certification, which recognizes inpatient programs that demonstrate exceptional patient- and family-centered interdisciplinary palliative care. The certification is the latest development in a decades-long quest to raise the profile of pain and palliative care. “Pain and palliative care is essential, specialty care. Every hospital needs to provide it through a skilled and compassionate, interdisciplinary team,” says Michael H. Levy, MD, PhD, vice chair of medical oncology, director of Fox Chase’s … Continue Reading »

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Pictured from left to right are Stephen M. Sykes, Sergei Grivennikov, Neil Johnson, James S. Duncan, and Glenn F. Rall.

On the Cutting Edge with New Principal Investigators

Attracting and cultivating talented early-career scientists has long been a hallmark of the culture at Fox Chase. Glenn F. Rall, associate chief academic officer and co-leader of the Immune Cell Development and Host Defense Program, sat down with four recently hired researchers — James S. Duncan, Sergei Grivennikov, Neil Johnson, and Stephen M. Sykes — to talk about what’s exciting at the bench. Continue Reading »

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Doss Named Outstanding Leader in Low Dose-Response

Medical physicist Mohan Doss, PhD, MCCPM, associate professor of diagnostic imaging, received the International Dose-Response Society’s 2014 Outstanding Leadership Award at the organization’s annual conference in April in Amherst, Mass. The award recognizes his contribution to a deeper understanding of the relationships between dose and response.

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Vascularized Lymph Node Transfer and Lymphovenous Bypass Provide Relief from Lymphedema

The TOPLINE In vascularized lymph node transplant, the surgeon transplants healthy lymph nodes into the area affected by lymphedema Lymphatic fluid collecting in the affected extremity drains into the venous circulation, reducing swelling In lymphovenous bypass, the surgeon connects lymphatic vessels to small blood vessels to drain fluid Fox Chase surgical oncologists Sameer A. Patel, MD, FACS, and Eric I. Chang, MD, are offering vascularized lymph node transfer, an innovative surgical procedure for treating lymphedema, a common condition for patients who have had their lymph nodes removed during cancer treatment. With lymphedema occurring in the arms of up to about … Continue Reading »

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Fox Chase Faculty Co-Write and Edit SCCHN Book

A new book co-edited by Fox Chase deputy chief scientific officer Erica A. Golemis, PhD, and Barbara Burtness, MD, formerly of Fox Chase and now at Yale Cancer Center, summarizes the unique pathobiology of head and neck cancers. Molecular Determinants of Head and Neck Cancer, one of very few books in its field, introduces the origins and subclasses of squamous cell carcinomas of the head and neck (SCCHNs) and how those factors impact disease profile and response to treatment. The book then summarizes current understanding of the genetic, epigenetic, and protein expression changes associated with various classes of the disease, … Continue Reading »

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Fox Chase Faculty Honored at Spring Meetings

At its annual meeting in May, the American Urological Association presented its 2014 Residents Committee Teaching Award to Robert G. Uzzo, MD, FACS, chair of surgical oncology. The award recognizes Uzzo as an outstanding urology program director who is dedicated to mentoring the next generation of urologic researchers. Michael H. Levy, MD, PhD, vice chair of medical oncology and director of pain and palliative care, was selected by the American Society of Clinical Oncology (ASCO) for its first ever Excellence in Teaching Award. The award, presented during ASCO’s 50th Annual Meeting in Chicago in May, honors recipients for inspiring and … Continue Reading »

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A Kaplan-Meier plot comparing survival in cohorts of SCCHN patients with high and normal 
expression of Aurora kinase A, based on data from The Cancer Genome Atlas. Inhibiting the activity of Aurora kinase A is expected to improve survival for patients with elevated levels of Aurora kinase A.

Trials Explore a Synergistic Therapeutic Combination for Head and Neck, Lung Cancer

Epidermal growth factor receptors (EGFRs) are proven to be effective molecular targets for anti-cancer drugs, but what happens when EGFRs are targeted in conjunction with a lesser-studied enzyme — Aurora kinase A? Clinical trials underway at Fox Chase are exploring the effectiveness of this “two-hit” therapeutic approach in head and neck cancer as well as lung cancer. Continue Reading »

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